Born from the clinical world of post-operative recovery, 111SKIN’s Repair Serum NAC Y²™ was never intended to be a commercial product. It was, quite simply, a solution — a formula designed by celebrated surgeon Dr. Yannis Alexandrides to help his patients heal.
Today, that same formula has become a global icon in performance-driven skincare — a bridge between cutting-edge medicine and luxury beauty, trusted by elite spas, dermatologists, and skincare connoisseurs worldwide.
A Serum Born in Surgery, Not a Lab
The origin of 111SKIN didn’t begin in a beauty laboratory — it began in an operating theatre on Harley Street, London’s prestigious medical district. As a board-certified facial plastic surgeon in both Europe and the US, Dr. Yannis sought a topical formula to enhance skin healing and resilience before and after surgery. Existing options were either too harsh, ineffective, or unsophisticated for his discerning clientele.
Partnering with co-founder and creative visionary Eva Alexandridis, he created a unique reparative serum powered by NAC Y²™, a proprietary complex that would go on to redefine the future of medical-grade skincare. What started as a surgeon’s backstage formula quietly made its way into treatment rooms — and eventually, onto luxury shelves around the world.
See also: 9 Light Therapy Machines That Work Like Magic
The Holy Grail of Skin Recovery
At the heart of the Repair Serum NAC Y²™ lies a trio of powerful actives:
- N-Acetyl Cysteine (NAC): a compound studied for its ability to combat oxidative stress — even in astronauts.
- Vitamin C: a radiance-boosting antioxidant that stabilizes NAC and supports skin defence.
- Escin: an anti-inflammatory extract that promotes microcirculation and reduces irritation.
Together, they form NAC Y²™, a precision-engineered complex that boosts glutathione — the body’s master antioxidant — and supports the skin’s natural recovery processes. Clinically inspired and results-driven, this serum became a cult favourite not through marketing, but through word of mouth and remarkable transformations.
From Clinic Secret to Cult Skincare
Initially developed for post-operative use at 111 Harley St., the Healing Serum became a well-kept secret among patients and industry insiders. Its reputation caught the attention of a buyer at Harrods, marking the brand’s first foray into retail and setting the stage for its global expansion.
In 2012, the newly named Repair Serum NAC Y²™ officially launched as the flagship product of 111SKIN. Over a decade later, it remains the brand’s hero — a clinically proven formula designed to help optimise skin health, shown to:
- Reduce redness and irritation
- Improve elasticity and firmness
- Deeply hydrate and smooth wrinkles
- Shield the skin against environmental and oxidative stress
Its continued success is a testament to the brand’s scientific integrity and luxury positioning.
See also:9 Facial Treatments You Should Try Now
Redefining Skincare with Surgical Precision
Guided by over 30 years of medical experience, Dr. Yannis continues to lead 111SKIN’s research and development, championing formulas that unite the rigour of medicine with the elegance of beauty. Every product is backed by clinical insight and subjected to meticulous testing — a rarity in the world of high-end skincare.
In 2025, 111SKIN was honoured as “Performance-Driven Skincare Brand of the Year” at the Destination Deluxe Awards 2025, recognising its unwavering commitment to excellence, efficacy, and innovation.
From Harley Street to holistic wellness retreats, 111SKIN stands as a pioneer — turning clinical-grade formulations into everyday luxury, and proving that great skincare can begin with healing, but end in radiance.
